GREEN TEA SKIN
INGREDIENTS SCIENTIFIC REFERENCES

PROPRIETARY INGREDIENT COMBINATION -
GREEN TEA EGCG, SANDALWOOD AND CORK BARK

GREEN TEA EGCG
Studies suggest skin benefits may include:
A) Diminishment of skin-damaging free radicals
B)  Anti-inflammatory properties
C) Anti-mutagenic properties
D) Delay of photo-aging
E)  Minimization of skin cell damage from ultraviolet radiation
F)  Repair of sun-damaged skin cells and minimization of sunburn
G)  Modulation of skin immune response
H) Preservation of skin cells
I)  Prevention of collagen cross-linking and breakdown.

These studies include human cell & tissue culture and clinical investigations:

1)    Song XZ, Bi ZG, Xu AE “Green Tea Polyphenol EGCG Inhibits the Expression of Nitric Acid Synthase and Generation of Nitric Oxide Induced by Ultraviolet B in HaCaT Cells” Chin Med J 2006 Feb 20;119(4):282-7

2)    Katiyar S, Elmet CA “Green Tea and Skin Cancer: Photoimmunology, Angiogenesis and DNA Repair” J Nutr Biochem 2006 Oct 16

3)    Cheng TO “Can Green Tea Protect Against Sunburn and Melanoma?” Chin Med J 2006 Kim 20;119(12):1056

4)    Xin J, Son X, Bi Z, Chu W, Wan Y “UV-Induced NF-kappaB Activation and Expression of IL-6 is Attenuated by Epigallocatechin-3-Gallate in Cultured Human Keratinocytes In Vitro” Int J Mol Med 2005 Nov;16(5):943-50

5)    An BJ, Kwak, JH, et al, “Physiological Activity of Irradiated Green Tea Polyphenol on the Human Skin” Am J Chin Med 2005 Aug;97(8): 1165-9

6)    Syed, T (University of San Francisco) “Green Tea Helps Reduce Redness and Inflammation in Women with Papopostular Rosacea” Presentation, American Academy of Dermatology Meeting, New Orleans, Feb, 2005   (CLINICAL)

7)    Lee JH, Chung JH, Cho KH “The Effects of Epigallocatechin-3-Gallate on Extracellular Metabolism” J Dermatol Sci 2005 Jul;31(7 Pt2):855-60

8)     Mantena SK, Roy AM, Katiyar SK “Epigallocatechin-3-Gallate Inhibits Photocarcinogenesis Through Inhibition of Angiogenic Factors and Activation of CD8(+) T Cells in Tumors” Dermatol Surg 2005 Sep-Oct;81(5):1174-9

9) Hsu S “Green Tea and the Skin” J Am Acad Dermatol 2005 Jun;52(6):1049-59

10) Lu YP, Lou YR, Liao J, et al, “Administration of Green Tea or Caffeine Enhances the Disappearance of UVB-Induced Patches of Mutant p53 Positive Epidermal Cells in SKH-1 Mice” Carcinogenesis 2005 Aug;26(8):1465-72

11) Huang CC, Fang JY, Wu WB, Chiang HS, et al, “Protective Effects of Epicatechin-3-Gallate on UVA-Induced Damage in HaCa T Keratinocytes” Arch Dermatol Res 2005 Apr;296(10):473-81

12) Balasubramanian S, et al “Human Epidermal Karitoncytes Undergo Epigallocatechin-3-Gallate Dependent Differentiation but Not Apoptosis” Carcingogenesis 2005 Jun;26(6):1100-8

13)  Morley N, Clifford T, et al, “The Green Tea Polyphenol Epigallocatechin Gallate and Green Tea Can Protect Human Cellular DNA for Ultraviolet and Visible Radiation-Induced Damage” Photodermatol Photoimmunol Photomed 2005 Feb;21(1):15-22

14)  Song XZ, Xia JP, Bi ZG, “Effects of Epigallocatechin Gallate on Expression of Matrix Metalloproteinase-1 and Tissue Inhibitor of Mattaloproteinase-1 Fibroplasts Irradiated with Ultraviolet A” Chin Med J 2004 Dec;117(12):1838-41

15)  Hsu S, Yamamoto T, Lapp C, et al “Green Tea Polyphenol-Induced Epidermal Keratinocyte Differentiation is Associated with Coordinated Expression of p57/KIP2 and Caspase 14” J Pharmacol Exp Ther 2005 Mar;312(3):884-90

16)  Batchelder RJ, Calder RJ, et al, “In Vitro Transdermal Delivery of the Major Catechins and Caffeine from Extract of Camellia Sinesis” Int J Pharm 2004 Sep 28;283(1-2):45-51

17)  Katiyar SK, “Skin Photoprotection by Green Tea: Antioxidant and Immunomodulatory Effects” Curr Drug Targets Immune Endocr Metabol Disord 2003 Sep;3(3):234-42

18)  Hsu S, Bollag WB, et al “Green Tea Polyphenols Induce Differentiation and Proliferation in Epidermal Keratinocytes” J Pharmacol Exp Ther 2003 Jul:306(1):29-34

19)  Afaq F, Adhami VM, et al “Inhibition of Ultraviolet B Mediated Activation of Nuclear Factor kappaB in Normal Human Epidermal Keratinocytes By Green Tea Constituent Epigallocatechin Gallate” Oncogenesis 2003 Feb 20:22(7); 1035-44

20)  Tobi SE, Gibert M, et al “The Green Tea Polyphenol EGCG Protects Against Oxidative Cellular and Genotoxic Damage of UVA Radiation” Intl J Cancer 2002;42(2)217-23

21)  Katiyar, SK, Bergamo BM, et al “Green Tea Polyphenols: DNA Photodamage and Photoimmunology” J Photochem Photobiol 2001 Dec 31;65(2-3) 108-14

22)  Proniuk S, Liederer BM, et al “Preformulation Study of EGCG, A Promising Antioxidant for Topical Skin Cancer Prevention” J Pharm Sci 2002 Jan:91(2) 111-6

23)  Katiyar, SK, Afaq F, et al “Inhibition of UVB-Induced Oxidative Stress-Mediated Phosphoylation of Nitrogen-Activated Protein Kinease Signaling Pathways in Cultured Human Epidermal Kartinocytes by Green Tea Polyphenol EGCG” Toxicol Appl Pharmacol 2001 Oct 15;176(2):110-7

24)  Elmets CA, Singh D et al “Cutaneous Photoprotection from Ultraviolet Injury by Green Tea Polyphenols” J Am Acad Dermatol 2001 Nr;44(3):425-32

25)  Katiyar SK, Afaq F, et al “Green Tea Polyphenol EGCG Treatment of Human Skin Inhibits Ultraviolet Radiation-Induced Oxidative Stress” Carcinogenesis 2001 Feb;22(2) 287-94

26)  Kim J, Hwang JS, et al, “Protective Effects of EGCG on UVA- and UVB-Induced Skin Damage” Skin Pharmacol Appl Skin Physiol 2001 Jan-Feb;14(1):11-9

27)  Katiyar SK, Perez A, et al “Green Tea Polyphenol Treatment to Human Skin Prevents Formation of Ultraviolet Light B-Induced Pyrimidine Dymers in DNA” Clin Cancer Res 2000 Oct;6(10):3864-9              (CLINICAL)

28)  Chen NY, Ma WY, et al, “Inhibition of Arsenite-Induced Apoptosis and AP-1 Activity by EGCG and Theaflavins” J Environ Pathol Toxicol Oncol 2000; 19(3): 287-95

29)  Katiyar SK, Ahmad N. et al, “Green Tea and Skin” Arch Dermatol 2000 Aug:136(8): 989-94

30)  Stratton SP, Dorr RT, et al “The State-Of-The-Art in Chemoprevention of Skin Cancer” Eur J Cancer 2000 Jun:36(10):1292-7

SANDALWOOD:

Studies suggest skin benefits may include:
A)   Chemopreventive effects
B)   Skin tumor and skin papilloma prevention

These studies include human cell and tissue culture investigations:
1) Kaur M, Agarwal C, et al “Skin Cancer Chemopreventive Agent (Alpha)-Santalol, Induces Apoptic Death of Human Epidermoid Carcinoma A431 Cells Via Caspase Activation Together with Dissipation of Mitochondrial Membrane Potential and CytoChome C Release”  Carcinogenesis 2005 Feb;26(2):369-80

2) Hongratanaworakit T, Heuberger E, Buchbaur G, “Evaluation of the Effects of East Indian Sandalwood Oil and Alpha-Santalol on Humans After Transdermal Absorption” Planta Med 2004 Jan;70(1):3-7

CORK BARK EXTRACT:
Studies suggest skin benefits may include:
A) Tensor (firming) and smoothing effect on skin

This study is a clinical investigation:
1) Coquet C, Bauza E, Oberto G, et al, “Quercus Suber Cork Extract     Displays a Tensor and Smoothing Effect on Human Skin: An In Vivo Study” Drugs Exp Clin Res 2005; 31(3):89-99 (CLINICAL)


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